ISSN 1866-8836
Клеточная терапия и трансплантация

OD-02. Medication commitment of the patients before allo-HSCT

Elmira I. Kolgaeva, Mikhail Yu. Drokov, Dmitri E. Vybornykh, Natalia N. Popova, Zoya V. Konova, Natalia M. Nikiforova, Feruza A. Omarova, Olga S. Starikova, Ekaterina D. Mikhaltsova, Mariya V. Dovydenko, Olga M. Koroleva, Anna A. Dmitrova, Darya S. Dubnyak, Vera A. Vasilyeva, Larisa A. Kuzmina, Elena N. Parovichnikova, Valery G. Savchenko

National Medical Research Center of Hematology, Moscow, Russia

Dr. Elmira I. Kolgaeva, phone: +7 (495) 614-90-42, e-mail:

doi 10.18620/ctt-1866-8836-2021-10-3-1-148


Сomplications and outcomes after transplantation of allogeneic hematopoietic stem cells are determined not only by biological factors, such as the status of disease, age, comorbidity, etc., but also depend on the patient’s commitment to follow the doctor’s recommendations. Our aim was to demonstrate the effect of gender upon medication commitment among patients undergoing allo-HSCT.

Materials and methods

We analyzed 23 patients who entered to the National Medical Research Center of Hematology of the Ministry of Health of the Russian Federation for allo-HSCT. Patients had diagnosis “Acute myeloid leukemia” – 10, with the diagnosis “Acute lymphoblastic leukemia” – 9 patients and 4 patients with myelodysplastic syndrome. The average age of the patients was 40 years. Sex distribution: man 9 (39%), women 14 (61%). Medication commitment was studied using a specialized questionnaire KOP-25. The answer to each question was evaluated in points, which were then summed up and quantitative indicators were calculated. On the basis of the obtained indicators, the indices of commitment expressed in conditional percentages were calculated: to modification of the lifestyle, to drug therapy, to medical care. The Mann-Whitney test was used for comparison between the two groups. Differences were considered statistically significant at p <0.05.


The median of commitment to medical care for men was 63% (57%-72%), for women – 82% (77%-87%). The differences in the groups were statistically significant. The median commitment to lifestyle modification for men was 60% (45%-74%), for women – 62% (51%-75%). Differences among groups are not statistically significant. The commitment to drug therapy for men was 73% (53%-87%), for women – 87% (78%-90%), the differences in the groups are also not statistically significant. Integral commitment to treatment for men was 65%, range from 53% to 81%, for women – 77%, range from 68% to 86%. We did not get statistically significant differences between the groups.


The commitment to lifestyle modification, drug therapy before allo-HSCT does not differ depending on gender. At the same time, the commitment to medical care in women is significantly higher than in men. The greater commitment of women to medical supervision can make a significant contribution to long-term results after transplantation.


Commitment to lifestyle modification, commitment to drug therapy, commitment to medical care, recipients of allo-HSCT.

Volume 10, Number 3

Download PDF version

doi 10.18620/ctt-1866-8836-2021-10-3-1-148

Back to the list