ISSN 1866-8836
Клеточная терапия и трансплантация

Cellular Therapy and Transplantation is an international, peer-reviewed, Open Access journal which publishes articles in the fields of cellular and gene therapy and tissue transplantation. We welcome original research articles, review articles, short communications and clinical case reports. The major criteria for acceptance and publication of a manuscript are originality, high quality, scientific rigor, and interest to a wide audience of readers. The journal is issued in printed and digital version (www.cttjournal.com)

Editorial work, processing and publication of the articles are free of charge for the authors.

Papers accepted for publication in CTT are made available on this site at no charge to readers (Open Access). The articles published in CTT are provided under the following license: Creative Commons Attribution 3.0 Unported, http://creativecommons.org/licenses/by/3.0/ Authors retain the copyright of their contributions.
Volume 7, Number 2
09/04/2018
Volume 7, Number 2
Editor-in-Chief
Afanasyev B. V. (St. Petersburg, Russia)
Co-Editors-in-Chief
Wagemaker G. (Rotterdam, Netherlands)
Zander A.R. (Hamburg, Germany)
Deputy Editor
Fehse B. (Hamburg, Germany)
Managing Editor
Chukhlovin A. B. (St. Petersburg, Russia)
Editorial Board
Aleynikova O. V. (Minsk, Belarus)
Borset M. (Trondheim, Norway)
Chechetkin A. V. (St. Petersburg, Russia)
Fibbe W. (Leiden, Netherlands)
Galibin O. V. (St. Petersburg, Russia)
Hölzer D. (Frankfurt a.M., Germany)
Klimko N. N. (St. Petersburg, Russia)
Kolb H.-J. (München, Germany)
Kröger N. (Hamburg, Germany)
Kulagin A. D. (St. Petersburg, Russia)
Lange C. (Hamburg, Germany)
Mamaev N. N. (St. Petersburg, Russia)
Mikhailova N. B. (St. Petersburg, Russia)
Moiseev I. S. (St. Petersburg, Russia)
Nagler A. (Tel-Aviv, Israel)
Nemkov A. S. (St. Petersburg, Russia)
Paramonov I. V. (Kirov, Russia)
Roumiantsev A. G. (Moscow, Russia)
Savchenko V. G. (Moscow, Russia)
Smirnov A. V. (St. Petersburg, Russia)
Uss A. L. (Minsk, Belarus)
Zubarovskaya L. S., (St. Petersburg, Russia)
In this Issue

The ongoing CTT number begins with a review article by Dr. A. Grigoriants et al. which deals with oral problems in the patients after allogeneic hematopoietic stem cell transplantation (HSCT), expecially, short- and long-term dental disorders in children after intensive cytotoxic therapy, and inflammatory/atrophic changes of oral mucosa associated with acute and chronic graft-versus-host disease (GVHD), due to infections and autoaggressive processes.

International data show good efficiency of haploidentical HSCT when treating acute leukemias. Appropriate clinical protocols for children and adolescents using non-manipulated hematopoietic grafts, and evaluation of medium- and long-term results are reported by Dr. O. Paina et al. The authors conclude on good efficiency of haploidentical HSCT for this age group, being comparable to HLA-compatible transplantation.

Novel inhibitors of PD-1 apoptotic pathway are intensively studied, aiming for enhanced immune therapy of different malignancies. The article by Dr. K. Lepik et al. concerns application of Nivolumab in relapsed Hodgkin’s disease (HD) following allogeneic HSCT. Most patients exhibited appreciable clinical response, thus confirming efficiency of this drug in HD.

Treatment of myelodysplastic syndromes and acute myeloblastic leukemias (AML) evolving from acquired aplastic anemia are discussed in the article by Dr. I. Golubovskaya et al. which presents clinical results obtained, when treating these rare conditions with complex pathogenesis. In particular, the authors discuss early complications and overall survival following immunosuppressive therapy and allo-HSCT.

The article by Dr. E. Babenko et al. presents a comparative statistical evaluation of transplantation with cryopreserved vs freshly taken hematopoietic grafts in a heterogenous patient sample. A long-term experience has generally shown that the results of allogeneic HSCT with cryopreserved graft are comparable to native hematopoietic transplants, in terms of severe acute and chronic GVHD, overall survival, and GVHD-relapse-free survival.

Expression of leukemia-associated genes, such as EVI 1, WT 1, etc., is important both for primary diagnostics, and, especially, for the minimal residual disease (MRD) quantitation after therapy. The study by Dr. A. Shakirova et al. is focused on prognostic significance and diagnostic cut-off values for BAALC gene expression predictive for high risk of relapse in acute myeloid leukemia after allo-HSCT.

Clinical value of cytogenetics for tracing clonal evolution in myelodysplastic syndrome is well illustrated by a clinical case presented by Prof. N. Mamaev et al. The case is quite instructive to oncohematologists since it compares clinical course, cytogenetic and molecular evolution in the patient.

A good experimental study is presented by a group from Novosibirsk (Dr. D. Matvienko et al.). The authors have produced a clone of CAR cells which could be potentially applied for immunotherapy of prostate cancer.

This issue also contains a concise comment by Professor Axel R. Zander, who presents the available clinical criteria for risk prediction in AML patients that was vividly discussed in two previous CTT journals. The readership is invited to follow the entire discussion in details.

Editorial article

Editorial article
Professor Boris V.Afanasyev, Editor-in-Chief, Cellular Therapy and Transplantation

Review articles

Stomatological problems and infectious complications after hematopoietic stem cell transplantation
Artur P. Grigoriants1, Ilya M. Rabinowitch2, Alexey B. Chukhlovin1

Clinical studies

Safety and efficacy of nivolumab applied at different dosage in the patients with relapsing Hodgkin lymphoma after allogeneic hematopoietic stem cell transplantation
Kirill V. Lepik, Andrey V. Kozlov, Evgeniya S. Borzenkova, Marina O. Popova, Ivan S. Moiseev, Elena I. Darskaya, Asmik G. Gevorgyan, Luibov A. Tsvetkova, Sergey N. Bondarenko, Alexander L. Alyanskiy, Elena V. Kondakova, Natalya B. Mikhailova, Boris V. Afanasyev
Ten-year experience of allogeneic haploidentical hematopoietic stem cell transplantation with non-manipulated grafts in children and adolescents with high-risk acute leukemia
Olesya V. Paina, Polina V. Kozhokar, Anastasia S. Borovkova, Anastasia S. Frolova, Kirill A. Ekushov, Tatyana A. Bykova, Zhemal Z. Rakhmanova, Mariya A. Galas, Aigul G. Khabirova, Inna V. Markova, Elena V. Semenova, Sergey N. Bondarenko, Elena V. Babenko, Tatyana L. Gindina, Alexander L. Alyanskiy, Ildar M. Barkhatov, Boris I. Smirnov, Ludmila S. Zubarovskaya, Boris V. Afanasyev
Myelodysplastic syndrome/acute myeloid leukemia evolving from aplastic anemia: Efficacy of hematopoietic stem cell transplantation
Irina K. Golubovskaya, Alexander D. Kulagin, Yulia V. Rudnitskaya, Elena V. Morozova, Anna A.Osipova, Varvara N. Ovechkina, Nikolay Y. Tсvetkov, Sergey N.Bondarenko, *Boris I. Smirnov, Ludmila S. Zubarovskaya, Inna V. Markova, Boris V. Afanasyev
Pair-matched study of cryopreserved versus native graft in adult and pediatric recipients of allogeneic hematopoietic stem cell transplantation
Elena V. Babenko, Ivan S. Moiseev, Mikhail M. Kanunnikov, Alexandr L. Alyanskiy, Dmitrii E. Pevcov, Anastasia V. Frolova, Anna A. Osipova, Tatyana A. Bykova, Olesya V. Paina, Elena I. Darskaya, Ludmila S. Zubarovskaya, Sergey N. Bondarenko, Inna V. Markova, Boris V. Afanasyev
Primary myelodysplastic syndrome with two rare recurrent chromosome abnormalities [t(3q26.2;q22) and trisomy 13] associated with resistance to chemotherapy and hematopoietic stem cell transplantation
Nikolay N. Mamaev, Tatiana L. Gindina, Elena V. Morozova, Yuliya V. Rudnitskaya, Maria V. Gubina, Ildar M. Barkhatov, Sergey N. Bondarenko, Boris V. Afanasyev
Prognostic significance of BAALC overexpression in patients with AML during the posttransplant period
Alena I. Shakirova, Ildar M. Barkhatov, Anna I. Churkina, Ivan S. Moiseev, Tatiana L. Gindina, Sergey N. Bondarenko, Boris V. Afanasyev

Experimental studies

Analysis of in vitro activity of PSCA-specific CARs in the context of human NK cell line YT
Daria A. Matvienko a, b, #, Sergey V. Kulemzin a, #, Anna S. Smagina a, b, Tatyana N. Belovezhets a, b, Anton N. Chikaev a, Olga Y. Volkova a, Nikolay A. Chikaev a, Olga A. Koval b, c, Elena V. Kuligina b, c, Alexandr V. Taranin a, b, Andrey A. Gorchakov a, b

Letter to the Editor

Letter to the Editor
Axel Rolf Zander