Cellular Therapy and Transplantation

Cellular Therapy and Transplantation is an international, peer-reviewed, Open Access journal which publishes articles in the fields of cellular and gene therapy and tissue transplantation. We welcome original research articles, review articles, short communications and clinical case reports. The major criteria for acceptance and publication of a manuscript are originality, high quality, scientific rigor, and interest to a wide audience of readers. The journal is issued in printed and digital version (www.cttjournal.com)

Editorial work, processing and publication of the articles are free of charge for the authors.

Papers accepted for publication in CTT are made available on this site at no charge to readers (Open Access). The articles published in CTT are provided under the following license: Creative Commons Attribution 3.0 Unported, http://creativecommons.org/licenses/by/3.0/ Authors retain the copyright of their contributions.

Volume 11, Number 3
10/31/2022

Editor-in-Chief
Kulagin A. D. (St. Petersburg, Russia)

Co-Editors-in-Chief
Wagemaker G. (Rotterdam, Netherlands)
Zander A. R. (Hamburg, Germany)

Deputy Editor
Fehse B. (Hamburg, Germany)

Managing Editor
Chukhlovin A. B. (St. Petersburg, Russia)

Editorial Board
Aleynikova O. V. (Minsk, Belarus)
Borset M. (Trondheim, Norway)
Chechetkin A. V. (St. Petersburg, Russia)
Fibbe W. (Leiden, Netherlands)
Gale R. P. (Los Angeles, USA)
Galibin O. V. (St. Petersburg, Russia)
Hehlmann R. (Mannheim, Germany)
Hölzer D. (Frankfurt a.M., Germany)
Klimko N. N. (St. Petersburg, Russia)
Kolb H.-J. (München, Germany)
Kröger N. (Hamburg, Germany)
Lange C. (Hamburg, Germany)
Mamaev N. N. (St. Petersburg, Russia)
Mikhailova N. B. (St. Petersburg, Russia)
Moiseev I. S. (St. Petersburg, Russia)
Nagler A. (Tel-Aviv, Israel)
Nemkov A. S. (St. Petersburg, Russia)
Paramonov I. V. (Kirov, Russia)
Roumiantsev A. G. (Moscow, Russia)
Smirnov A. V. (St. Petersburg, Russia)
Uss A. L. (Minsk, Belarus)
Zubarovskaya L. S. (St. Petersburg, Russia)

In this Issue

Editorial article

XVI Raisa Gorbacheva Memorial Meeting Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy

Alexander D. Kulagin, Editor-in-Chief, Cellular Therapy and Transplantation

Award Session: AW-01 – AW-04

AW-01. Transplantation of human hematopoietic stem cells with CCR5 knock out by CCR5-Uco-TALEN nuclease to NBSGW mice: pilot study

Yaroslava V. Komarova¹, Alena I. Shakirova¹, Vladislav S. Sergeev¹, Svetlana A. Osipova², Ekaterina V. Shchelina², Anatoliya V. Onopchenko², Marina L. Vasutina², Olga G. Bredneva², Kirill S. Yakovlev³, Yana R. Orshanskaya³, Konstantin V. Sivak³, Timofey E. Karpov¹, Albert R. Muslimov¹, Marina O. Popova¹, Kirill V. Lepik¹, Alexander D. Kulagin¹

AW-02. Allogeneic hematopoietic stem cell transplantation in the treatment of peripheral T-cell lymphomas: a multicenter experience

Elena E. Lepik¹, Vladislav V. Kovalik¹, Andrey V. Kozlov¹, Evgenia S. Borzenkova¹, Kirill V. Lepik¹, Elena V. Kondakova¹, Nikita P. Volkov¹, Vadim V. Baykov¹, Marina O. Popova¹, Ivan S. Moiseev¹, Tatiana V. Shneider², Olga S. Uspenskaya², Marina V. Demchenkova³, Vera V. Sergeevicheva⁴, Vadim M. Kemaikin⁵, Gayane S. Tumyan⁶, Anastasia A. Semenova⁶, Ilya S. Zyuzgin⁷, Natalia B. Mikhailova¹, Alexander D. Kulagin¹

AW-03. Prophylactic and preventive therapy with azacitidine and donor lymphocyte infusions after allo-HSCT in children with acute myeloid leukemia

Liubov A. Tsvetkova, Olesya V. Paina, Zhemal Z. Rakhmanova, Anna A. Osipova, Polina V. Kozhokar, Аnastasia S. Frolova, Elena V. Semenova, Alexander D. Kulagin, Ludmila S. Zubarovskaya

AW-04. Optimization of aseptic care techniques for central venous catheter in patients with hematological diseases

Tamara A. Gogoleva

Acute leukemias: AL-01 – AL-10

AL-01. First experience in diagnosis and treatment of Philadelphia chromosome-like acute lymphoblastic leukemia

Kseniia S. Afanaseva, Polina V. Sheveleva, Olga V. Pirogova, Anna G. Smirnova, Olesya V. Paina, Ildar M. Barkhatov, Tatiana L. Gindina, Elena V. Babenko, Ivan S. Moiseev, Sergey N. Bondarenko, Ludmila S. Zubarovskaya, Alexander D. Kulagin

AL-02. Treatment options for adult patients with refractory/relapsed acute myeloid leukemia

Bella I. Ayubova¹, Sergey N. Bondarenko¹, Ivan S. Moiseev¹, Anna G. Smirnova¹, Olga S. Uspenskaya², Elena V. Karyagina³, Evgenia I. Zhelnova⁴, Elena V. Babenko¹, Ildar M. Barkhatov¹, Tatyana L. Gindina¹, Alexander D. Kulagin¹

AL-03. Gilteritinib as a bridge to allogeneic hematopoietic stem cell transplantation in adult patients with refractory/relapsed acute myeloid leukemia with FLT3 mutations

Bella I. Ayubova¹, Sergey N. Bondarenko¹, Anna G. Smirnova¹, Yulia Yu. Vlasova¹, Nikolay Yu. Tsvetkov¹, Michail M. Kanunnikov¹, Dmitry K. Zhogolev¹, Yuliya D. Oleynikova¹, Elena V. Karyagina², Ridvan K. Ilyasov³, Natalya A. Zorina⁴, Svetlana S. Belyaeva⁵, Yulia S. Neredko⁶, Irina A. Samorodova⁷, Yulia B. Chernih⁸, Mikhail Yu. Lazarev⁹, Anna P. Kochergina¹⁰, Anna A. Nasredinova¹, Ildar M. Barkhatov¹, Tatyana L. Gindina¹, Ivan S. Moiseev¹, Alexander D. Kulagin¹

AL-04. Midostaurin in adult patients with de novo diagnosed FLT3-positive acute myeloid leukemia

Sergey N. Bondarenko¹, Anna G. Smirnova¹, Bella I. Ayubova¹, Yulia Y. Vlasova¹, Elena V. Karyagina², Olga S. Uspenskaya³, Yulia S. Neredko⁴, Elena A. Pashneva⁵, Anna P. Kochergina⁶, Natalia B. Esefyeva⁷, Tatyana I. Brazkina⁸, Ridvan K. Ilyasov⁹, Yulia B. Chernih¹⁰, Yurii A. Dunaev¹¹, Irina A. Samorodova¹², Olesia G. Smykova¹, Ksenia S. Yurovskaya¹, Dmitrii K. Zhogolev¹, Michail M. Kanunnikov¹, Yulia D. Oleynikova¹, Ildar M. Barkhatov¹, Tatiana L. Gindina¹, Ivan S. Moiseev¹, Alexander D. Kulagin¹

AL-05. First results of the “Cooperative Program for Diagnosis and Treatment of Acute Myeloid Leukemia in Russian Federation” implementation

Sergey N. Bondarenko¹, Dmitrii K. Zhogolev¹, Bella I. Ayubova¹, Anna G. Smirnova¹, Tatiana L. Gindina¹, Elena V. Babenko¹, Ildar M. Barkhatov¹, Natalia E. Ivanova¹, Tatiana S. Shchegoleva¹, Veronika V. Ermolina¹, Nikita P. Volkov¹, Varvara I. Bakhtina², Natalya N. Glonina³, Ksenia S. Dedyukhina⁴, Yuri A. Dunaev⁵, Tatiana S. Kaporskaya⁶, Elena G. Kirillova⁷, Vladimir A. Kobiyasov⁸, Tatiana S. Konstantinova⁹, Marina V. Kosinova¹⁰, Tatiana I. Ksenzova¹¹, Alexander A. Myasnikov¹², Irina A. Novokreshenova¹³, Olesya S. Kuznetsova¹⁴, Tatiana I. Olkhovik¹⁵, Elena A. Pashneva¹⁶, Anastasia G. Petukhova¹⁷, Andrey V. Proydakov¹⁸, Kirill V. Rytov¹⁹, Victoria V. Ryabchikova²⁰, Irina A. Samorodova²⁰, Olga S. Samoilova²¹, Irina V. Trukhan²², Ekaterina A. Ukrainchenko²³, Olga S. Uspenskaya²⁴, Maria V. Frolova²⁵, Yuri V. Shatokhin²⁶, Rada H. Ebzeeva²⁷, Angelina V. Talko²⁸, Konstantin P. Novoselov²⁹, Alina G. Karpova³⁰, Ivan S. Moiseev¹, Alexander D. Kulagin¹

AL-06. Influence of allogeneic hematopoietic stem cell transplantation on the treatment outcomes in patients with Ph-positive acute B-lymphoblastic leukaemia

Valeriia C. Luchkina, Olga A. Aleshina, Zalina T. Fidarova, Larisa A. Kuzmina, Galina A. Isinova, Ekaterina S. Kotova, Anastasia N. Vasileva, Sergey N. Bondarenko, Valerii A. Lapin, Zalina Kh. Akhmerzaeva, Mikhail Y. Drokov, Vera V. Troitskaya, Elena N. Parovichnikova

AL-07. Modern approaches to predicting post-transplant relapse of acute myeloid leukemia in children

Zhemal Z. Rakhmanova, Olesya V. Paina, Ildar M. Barkhatov, Ilya V. Kazantsev, Ayrat M. Sadykov, Svetlana V. Razumova, Polina V. Kozhokar, Anastasiya S. Frolova, Liubov A. Tsvetkova, Elena V. Babenko, Tatyana L. Gindina, Alexander L. Alyanskiy, Elena V. Semenova, Ludmila S. Zubarovskaya

AL-08. Heterogeneity of t(10;11) translocation with KMT2A-MLLT10 molecular product in patients with acute myeloid leukemia

Maria V. Stegantseva¹, Darya R. Kapuza¹, Julia A. Barouskaya¹, Maria G. Naumovich¹, Veronika А. Astramovich¹, Olga V. Aleinikova²

AL-09. The experience with asciminib as a bridge- therapy before allogeneic bone marrow transplantation

Yulia Yu. Vlasova, Elena V. Morozova, Ksenia S. Yurovskaya, Tatiana A. Rudakova, Tatiana L. Gindina, Ildar M. Barkhatov, Ivan S. Moiseev, Alexander D. Kulagin

AL-10. Clinical features of cytokine release syndrome in adult patients with acute leukemia after allogeneic stem cell transplantation: RM Gorbacheva Research Institute experience

Nikita P. Volkov, Julia V. Kotova, Maria D. Vladovskaya, Jaroslav B. Skiba, Dmitrii K. Zhogolev, Kseniia S. Afanaseva, Yulia Yu. Vlasova, Sergey N. Bondarenko, Marina O. Popova, Yuliya A. Rogacheva, Ivan S. Moiseev

Lymphomas: LY-01 – LY-08

LY-01. Myeloid-derived supressor cells and their suppressive potential after autologous hematopoietic stem cell transplantation in patients with multiple myeloma

Tatyana A. Aristova, Tamara V. Tyrinova, Egor V. Batorov, Vera V. Denisova, Svetlana A. Sizikova, Galina Yu. Ushakova, Ekaterina Y. Shevela, Alexander A. Ostanin, Elena R. Chernykh

LY-02. Treatment strategy of patients with relapsed and refractory aggressive B-cell non-Hodgkin lymphoma

Liudmila V. Fedorova, Olesya G. Smykova, Andrey M. Chekalov, Marina O. Popova, Vladislav V. Markelov, Elena V. Kondakova, Ivan S. Moiseev, Kirill V. Lepik, Natalia B. Mikhailova, Alexander D. Kulagin

LY-03. Long-term multicenter study of nivolumab efficacy and safety in patients with relapsed and refractory classic Hodgkin lymphoma

Yaroslava V. Komarova¹, Ludmila V. Fedorova¹, Marina V. Demchenkova², Maria V. Grigorieva², Polina V. Kotselyabina¹, Andrey M. Chekalov¹, Elena E. Lepik¹, Elena V. Kondakova¹, Evgenia S. Borzenkova¹, Vadim V. Baykov¹, Marina O. Popova¹, Ivan S. Moiseev¹, Kirill V. Lepik¹, Natalia B. Mikhailova¹, Alexander D. Kulagin¹

LY-04. Prospective study: autologous hematopoietic stem cell transplantation in patients with HIV-related lymphoma

Marina O. Popova, Yuliya A. Rogacheva, Andrey M. Chekalov, Ivan V. Tsygankov, Kirill V. Lepik, Lilia V. Stelmakh, Vadim V. Baykov, Natalia B. Mikhailova, Alexander D. Kulagin

LY-05. Comparison of toxicity and efficacy of BeEAC, LEAM, and CLV conditioning regimens before autologous stem cell transplantation for treatment of primary-refractory and relapsed forms of Hodgkin’s lymphoma

Anastasiia A. Samoylova, Vladislav O. Sarzhevskiy, Vladimir Ya. Melnichenko, Nikita E. Mochkin, Anatoliy A. Rukavitsyn, Elena G. Smirnova, Vladimir S. Bogatyrev, Anna E. Bannikova

LY-06. Quality control of peripheral hematopoietic blood stem cells transplants obtained by G-CSF and plerixafor-induced mobilization in patients with multiple myeloma

Zarui K. Simavonyan, Anait D. Davtyan, Irina V. Kobzeva, Tatiana A. Astrelina, Yuliya B. Suchkova, Elena K. Sokolova

LY-07. Immunochemotherapy with nivolumab, bendamustine, gemcitabine and rituximab (BeGeRN) in relapsed or refractory B-cell Non-Hodgkin Lymphoma: NCT03259529

Olesya G. Smykova, Vladislav V. Markelov, Kirill V. Lepik, Elena V. Kondakova, Lilia V. Stelmakh, Ivan S. Moiseev, Natalia B. Mikhailova, Alexander D. Kulagin

LY-08. First-line therapeutic strategy and clinical prognosis in the patients with marginal zone lymphoma: Pavlov University experience

Lina B. Surina, Polina V. Kotselyabina, Kirill V. Lepik, Elena V. Kondakova, Liudmila V. Fedorova, Marina O. Popova, Natalia B. Mikhailova, Alexander D. Kulagin

Chronic hematological malignancies: CM-01 – CM-05

CM-01. Comparison of prognosis between patients with therapy-related myelodysplastic syndrome after hematological malignancies and myelodysplastic syndrome de novo: retrospective cohort study

Polina V. Kotselyabina, Vladislav V. Kovalik, Vladislav V. Markelov, Nikita N. Burlov, Kirill V. Lepik, Natalia B. Mikhailova, Olga B. Kalashnikova, Nikolay Y. Tsvetkov, Ksenia S. Yurovskaya, Tatiana L. Gindina, Ivan S. Moiseev, Alexander D. Kulagin, Elena V. Morozova

CM-02. Inflammatory cytokines perturb NK cell cytotoxicity and gene signature in myeloid leukemia

Valeriya V. Kuznetsova, Amanda F. Costa, Sweta B. Patel, Francesca Luca, Victoria R. Matkins, Alana M. Franceski, Paran Goel, Robert S. Welner

CM-03. Kidney function and survival of patients with chronic lymphocytic leukemia

Maria V. Markovtseva¹, Ekaterina N. Zguralskaya²

CM-04. Characteristics and treatment of blast crisis in chronic myeloid leukemia

Julia S. Yakovleva, Ksenia S. Yurovskaya, Yulia Yu. Vlasova, Ivan S. Moiseev, Elena V. Morozova

CM-05. Determining predictors of unfavorable course in low- and intermediate-risk patients with myelodysplastic syndrome

Ksenia S. Yurovskaya, Elena V. Morozova, Maria V. Barabanshchikova, Nikolay Y. Tsvetkov, Yulia Yu. Vlasova, Tatiana L. Gindina, Ildar M. Barkhatov, Ivan S. Moiseev, Alexander D. Kulagin

Hematopoiesis failure, anemias: HA-01 – HA-05

HA-01. The influence of conditioning regimen on recovery of fertility following allogeneic stem cell transplantation in aplastic anemia patients

Darya A. Chebykina, Irina K. Golubovskaya, Nikita P. Volkov, Ivan S. Moiseev

HA-02. Genetic mutations in children with acquired aplastic anemia

Irma V. Yemialyanova, Tatiana А. Uglova, Alexander А. Migas, Olga V. Aleinikova

HA-03. Allo-HSCT in sickle cell anemia and thalassemia: a case presentation

Lusine M. Krmoyan¹, Mane S. Gizhlaryan¹, Karen H. Meliksetyan¹, Narine A. Ghazaryan¹, Dianna R. Soghomonyan¹, Nelli O. Musayelyan¹, Armine A. Pepanyan¹, Andranik G. Shamilyan¹, Vahe A. Mayilyan¹, Inga V. Khalatyan¹, Taguhi J. Hovhannisyan¹, Melanya S. Sahakyan¹, Emma Tadevosyan¹, Gevorg N. Tamamyan¹, Samvel H. Danielyan¹, Lawrence Faulkner²

HA-04. Effects of immunopeptidome diversity on the development of graft failure in patients with acute leukemia

Feruza A. Omarova, Mikhail Yu. Drokov, Ekaterina G. Khamaganova, Natalia N. Popova, Olga S. Starikova, Ulyana V. Maslikova, Zoya V. Konova, Elmira I. Kolgaeva, Ekaterina D. Mikhaltsova, Mariya V. Dovydenko, Olga M. Koroleva, Anna A. Dmitrova, Darya S. Dubnyak, Mobil I. Akhmedov, Vera A. Vasilyeva, Larisa A. Kuzmina, Elena N. Parovichnikova

HA-05. Long-term results of immunosuppressive therapy in patients with aplastic anemia

Irina A. Tsopova, Erbol M. Sadabaev, Sagynaly M. Mamatov, Irina E. Kononets

Immune complications: IC-01 – IC-05

IC-01. The role of NK-cells associated factors in outcomes of haploidentical hemopoietic stem cells transplantation performed after selective depletions

Svetlana Yu. Glushkova, Viktoria A. Vedmedskaya, Dmitriy E. Pershin, Yakov O. Muzalevskii, Alexei S. Kazachenok, Elena E. Kurnikova, Svetlana A. Radygina, Maria A. Ilushina, Rimma D. Khismatullina, Larisa N. Shelikhova, Dmitriy E. Balashov, Alexei A. Maschan, Michael A. Maschan

IC-02. The use of ruxolitinib in combination with extracorporeal photopheresis in patients with steroid-refractory acute and chronic graft-versus-host disease

Nune A. Kambaryan, Anna A. Dotsenko, Tatiana A. Bykova, Yulia Yu. Vlasova, Anna A. Osipova, Olesya V. Paina, Anna G. Smirnova, Elena V. Morozova, Ludmila S. Zubarovskaya, Ivan S. Moiseev

IC-03. Combination of bendamustine and cyclophosphamide in graft-versus-host disease prophylaxis in refractory myeloid neoplasms: promising approach to augmentation of graft-versus-leukemia effect

Ivan S. Moiseev, Yulia Yu. Vlasova, Elena V. Morozova, Olga S. Epifanovskaya, Ksenia S. Afanaseva, Anastasia V. Beynarovich, Dmitry K. Zhogolev, Mikhail M. Kanunnikov, Yulia A. Rogacheva, Tatiana N. Rudakova, Nikita P. Volkov, Sergey N. Bondarenko, Alexander D. Kulagin

IC-04. Comparison of different T-helper cell populations in patients with and without chronic graft-versus-host disease after allo-HSCT for acute leukemia

Olga S. Starikova, Mikhail Y. Drokov, Nikolai M. Kapranov, Irina V. Galtseva, Ekaterina G. Khamaganova, Ksenia A. Nikiforova, Yulia O. Davydova, Vera A. Vasilyeva, Ekaterina D. Mikhaltsova, Natalia N. Popova, Daria S. Dubnyak, Anna A. Dmitrova, Olga M. Koroleva, Zoya V. Konova, Mobil I. Akhmedov, Maria V. Dovydenko, Uliana V. Maslikova, Feruza A. Omarova, Elmira I. Kolgaeva, Mironova D.A., Inara S. Saidullaeva, Luiza A. Karaseva, Larisa A. Kuzmina, Elena N. Parovichnikova, Valery G. Savchenko

IC-05. Ruxolitinib as a treatment of steroid-refractory acute and chronic graft-versus-host disease in children

Anna A. Zvyagintseva, Ivan S. Moiseev, Tatyana A. Bykova, Olesya V. Paina, Anna A. Osipova, Ludmila S. Zubarovskaya

Posttransplant infections: PI-01 – PI-08

PI-01. Invasive fungal diseases of the maxillofacial region, nasal cavity and paranasal sinuses in hematological patients and patients with post-COVID syndrome

Irina B. Baranova^1,2, Andrey I. Yaremenko¹, Marina O. Popova², Yulia A. Rodneva^2,3, Oleg I. Dolgov^2,3, Anna A. Zubareva³, Ilya Yu. Nikolaev², Olga N. Pinegina⁵, Margarita V. Malyarevskaya⁶, Sergey A. Karpishchenko³, Аlena N. Zaitseva², Alexander N. Shvetsov², Тatyana А. Bykovа², Olesya V. Paina², Oleg V. Goloshchapov², Sergey N. Bondarenko², Ludmila S. Zubarovskaya², Nikolay N. Klimko⁴, Alexander D. Kulagin²

PI-02. Conducting allo-HSCT in children under the conditions of COVID-19 pandemic

Natalia P. Gusleva, Olga O. Molostova, Olga V. Pimenova, Larisa N. Shelikhova, Michael A. Maschan

PI-03. Invasive aspergillosis in patients with hematological malignancies due to cryptic pathogens

Vladislav V. Markelov¹, Marina O. Popova¹, Yuliya A. Rogacheva¹, Olga N. Pinegina¹, Alisa G. Volkova¹, Ilia Y. Nikolaev¹, Nikita P. Volkov¹, Tatiana S. Bogomolova², Oleg V. Goloshchapov¹, Olesya V. Paina¹, Yulia Yu. Vlasova¹, Sergey N. Bondarenko¹, Nikolay N. Klimko^1,2, Ludmila S. Zubarovskaya¹, Alexander D. Kulagin¹

PI-04. Sepsis in early post-transplant period: new approaches to treatment

Nune V. Matinyan, Tatyana V. Gorbunova, Timur T. Valiev, Irina O. Kostareva, Timur. Z. Aliev, Natalya A. Burlaka, Natalya A. Batmanova,Vasiliy P. Akimov, Elena G. Gromova, Kirill I. Kirgizov, Svetlana R. Varfolomeeva

PI-05. Invasive fusariosis in patients with hematological and oncohematological diseases

Olga N. Pinegina¹, Marina O. Popova², Yuliya A. Rogacheva², Irina B. Baranova², Yulia A. Rodneva², Alisa G. Volkova², Ilya Yu. Nikolaev², Alena N. Zaitseva², Alexander N. Shvetsov², Stanislav D. Gorbunkov³, Anna A. Spiridonova¹, Oleg V. Goloshchapov², Tatyana A. Bykova², Bella I. Ayubova², Maria V. Bogomolova², Andrey L. Akopov³, Ludmila S. Zubarovskaya², Sergey N. Bondarenko², Alexander D. Kulagin²