ISSN 1866-8836
Клеточная терапия и трансплантация
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Volume 1, Number 2
Volume 1, Number 2
Afanasyev B. V. (St. Petersburg, Russia)
Wagemaker G. (Rotterdam, Netherlands)
Zander A. (Hamburg, Germany)
Deputy Editor
Chukhlovin A. B. (St. Petersburg, Russia)
Fehse B. (Hamburg, Germany)
Novik A. (Moscow, Russia)
Managing Editor
Claudia Koltzenburg (Hamburg, Germany)
Editorial Board
Aleynikova O. (Minsk, Belarus)
Alyansky A. (St. Petersburg, Russia)
Anagnostou A. (Boston, USA)
Andreeff M. (Houston, USA)
Bacher U. (Hamburg, Germany)
Baуkov V. (St. Petersburg, Russia)
Baranov V. S. (St. Petersburg, Russia)
Barkhatov I. (St. Petersburg, Russia)
Baum C. (Hannover, Germany)
Bilko N. (Kiev, Ukraine)
Borset M. (Trondheim, Norway)
Buechner Th. (Muenster, Germany)
Bykov V. (St. Petersburg, Russia)
Dini G. (Genoa, Italy)
Drize N. (Moscow, Russia)
Egeland T. (Oslo, Norway)
Elstner E. (Berlin, Germany)
Emanuel V. (St. Petersburg, Russia)
Everaus H. (Tartu, Estonia)
Ferrara J. (Ann Arbor, USA)
Fibbe W. (Leiden, Netherlands)
Galibin O. (St. Petersburg, Russia)
Ganser A. (Hannover, Germany)
Granov D. (St. Petersburg, Russia)
Ivanov R. (Moscow, Russia)
Klimko N. (St. Petersburg, Russia)
Kolb H.-J. (Muenchen, Germany)
Konopleva M. (Houston, USA)
Koza V. (Pilsen, Czech Republic)
Kroeger N. (Hamburg, Germany)
Malikov A. (St. Petersburg, Russia)
Mikhailova N. (St. Petersburg, Russia)
Mentkevich G. (Moscow, Russia)
Nagler A. (Tel Hashomer, Israel)
Nemkov A. (St. Petersburg, Russia)
Neth R. (Hamburg, Germany)
Nevorotin A.J. (St. Petersburg, Russia)
Ostertag W. (Hamburg, Germany)
Palutke M. (Detroit, USA)
Roumiantsev A. G. (Moscow, Russia)
Savchenko V. G. (Moscow, Russia)
Smirnov A. V. (St. Petersburg, Russia)
Stamm C. (Berlin, Germany)
Tetz V. (St. Petersburg, Russia)
To B. (Adelaide, Australia)
Totolian A. A. (St. Petersburg, Russia)
Uss A.L. (Minsk, Belarus)
Vilesov A. (St. Petersburg, Russia)
Westenfelder Ch. (Salt Lake City, USA)
Wisloff F. (Oslo, Norway)
Zubarovskaya L. (St. Petersburg, Russia)
Zvartau E. (St. Petersburg, Russia)
Editorial Council
In this Issue

Stepping ahead

Only a few months have passed since the launch issue of CTT, and the feedback from authors, reviewers, and readers has been a rewarding experience.

Apart from current articles and reviews on an interesting range of topics, this issue contains a special section on mesenchymal cell therapy, with 7 articles out of 15 dedicated to this topic.

In the same section, in addition to the MSC articles, Mariusz Z. Ratajczak et al. introduce the very small embryonic-like stem cells (VSEL) and their potential for the regeneration of tissues.

From a related field, we publish „In and out of mitosis“, Tim Hunt‘s Special Lecture given at the Wilsede Meeting 2008. This is published jointly with our sister portal, whose multimedia resources we are starting to make available to a wider audience.

We particularly wish to encourage young medical researchers to get their cutting edge work peer-reviewed and published in CTT. From this issue onwards, the Contents page will include an icon called „FirstIA“ to highlight the authors for whom this CTT article is their first international article.

We would like to thank the following colleagues for undertaking the peer reviews for this issue of CTT: Ulrike Bacher, Alexey B. Chukhlovin, Boris Fehse, Nikolay N. Klimko, Nicolaus Kröger, Claudia Lange, Katarina Le Blanc, Nikolai N. Mamaev, and Ludmila S. Zubarovskaya.

Boris Vladimirovich Afanasyev and Axel Rolf Zander

Your Managing editor speaking

Since CTT is an open access journal, readers as well as authors can benefit enormously. How do authors benefit? You can link directly from your publication lists on the web to your CTT article. Your reader can click on a link that makes the article accessible immediately and without any cost barriers. This means that any web reader anywhere has access to your article and, without any extra effort, can cite your CTT article in their work.

CTT articles are already being indexed in CAS and DOAJ, with more visibility measures to come.

It is a great pleasure for me to run this journal on the managerial and production side together with our Editorial Office team located in both Hamburg and St. Petersburg. Our production team, too, is a meeting point for different lines of thought and it is an exceptional experience to develop a scientific journal together in managerial and technological respects.

I wish to thank the following colleagues for helping us start off so well: (with Michael Hirdes, Gina Steiner and Michael Sendke), René Hornung, Liudmila Lashkouskaya, Viktoriya Levenko, Yana Onikiychuk, Melissa Pritchard, Jutta Roebers, Anna Starikova, and Oksana Zhebel.

If you as authors and/or readers wish to contribute any questions, suggestions or comments, these are highly appreciated. Feel free to contact me directly, thank you.

Claudia Koltzenburg


Articles on mesenchymal cell therapy

Initial report on a phase I clinical trial: Prevention and treatment of post-operative Acute Kidney Injury with allogeneic Mesenchymal Stem Cells in patients who require on-pump cardiac surgery

Anna Gooch1, John Doty2, Jean Flores2, LeAnne Swenson2, Florian E Toegel1,3, George R Reiss4, Claudia Lange5, Axel R Zander5, Zhuma Hu1, Scott Poole1, Ping Zhang1 and Christof Westenfelder1,6 

A unique population of mobile very small embryonic/epiblast like (VSEL) stem cells resides in adult tissues: physiological and pathological consequences

Mariusz Z. Ratajczak1,2, Magda Kucia1, Dong-Myung Shin1, Liu Rui1, Justyna Drukala1, Wojtek Marlicz2, Janina Ratajczak1, Ewa K. Zuba-Surma1

Composition and functional properties of monolayer cell culture from human umbilical cord blood

Barkhatov I. M.1, Roumiantsev S. A.2, Vladimirskaya E. B.2, Afanasyev B. V.1

Experience of clinical mesenchymal stem cells (MSCs) usage for prophylaxis and GVHD treatment in patients undergoing allo-HSCT

Stankevich Y.1, Golovacheva A.1, Babenko E.1, Alyansky A.1, Paina O.1, Zubarovskaya L.1, Semenova E.1, Polintsev D.2,
Kruglyakov P.2, Afanasyev B.1

Autologous hematopoietic stem cell transplantation in multiple sclerosis

Yury L. Shevchenko1, Andrei A. Novik1, Alexey N. Kuznetsov1, Boris V. Afanasiev2, Igor A. Lisukov3, Oleg A. Rykavicin4, Аlexandr A. Myasnikov5, Vladimir Y. Melnichenko1, Denis A. Fedorenko1, Tatyana I. Ionova6, Roman A. Ivanov1, and Gary Gorodokin7 on behalf of the Russian Cooperative Group for Cellular Therapy

Review articles on mesenchymal cell therapy

Mesenchymal stem cells: precursor hierarchy

Irina Shipounova (Nifontova), Daria Svinareva, Josef Chertkov, Nina Drize

Platelet lysate for rapid expansion of human mesenchymal stromal cells

Claudia Lange, Figen Cakiroglu, Andrej Spiess, Heike Cappallo-Obermann, Axel R. Zander


Caspofungin as secondary prophylaxis or therapy in patients undergoing allogeneic stem cell transplantation with a prior or ongoing history of systemic or invasive fungal infections

N. Stute, T. Zabelina, N. Fehse, W. Hassenpflug, J. Panse, C. Wolschke, F. Ayuk, H. Schieder, H. Renges, A. Kratochwille, R. von Hinüber, R. Erttmann, A.R. Zander, N. Kröger

The use of Imatinib mesylate in Nigerians with chronic myeloid leukemia

Prof. Muheez A. Durosinmi1, Prof. Julius O. Faluyi2, Dr. Anthony A. Oyekunle1, Dr. Lateef Salawu1, Dr. Ismail A. Adediran1, Dr. Norah O. Akinola1, Oluwakemi O. Bamgbade3, Dr. Charles C. Okanny4, Dr. Sulaiman Akanmu4, Dr. Oche P. Ogbe5, Dr. Tambi T. Wakama5, Dr. Chijoke A. Nwauche6, Dr. Matthew E. Enosolease7, Dr. Daye N.K. Halim7, Dr. Godwin N. Bazuaye7, Dr. Chide E. Okocha8, Dr. J. A. Olaniyi9, Dr. Titi S. Akingbola9, Dr. Victor O. Mabayoje10, Dr. Ajani A. Raji10, Dr. Aisha Mamman11, Dr. Aisha Kuliya-Gwarzo12, Dr. Obike G. Ibegbulam13, Dr. Sunday Ocheni13, Dr. Yohanna Tanko14, Dr. Oladimeji P. Arewa1, Dr. Rahman A.A. Bolarinwa1, Dr. Davidson O. Kassim1, Dr. Mohammed A. Ndakotsu1, Dr. Omotilewa A. Amusu15, Prof. O. O. Akinyanju16

Clonal composition of hematopoietic tissue in reconstituted mice after repeated treatment with G-CSF

Irina Shipounova (Nifontova), Natalia Sats, Daria Svinareva, Tatiana Petrova, Nina Drize, Valeriy Savchenko

Detecting the V617F mutation of the Jak2 gene in patients with myeloproliferative disorders

Irina Y. Saburova, Yana S. Onikiychuk, Irina I. Zotova, Galina N. Sologub, Mikhail I. Zarayskiy

Review articles

Generation of regulatory T cells by T cell receptor gene transfer

Graham P. Wright, Judy Wai-Ling King and Hans J. Stauss

Advances in T cell receptor gene transfer for immunotherapy

Judy Wai-Ling King, Graham P. Wright and Hans J. Stauss