ISSN 1866-8836
Клеточная терапия и трансплантация

GC-01. CaCO3 nuclei as components of doxorubicin targeted delivery systems for the treatment of solid tumors

Oleg V. Galibin2, Natalia N. Sudareva1,2, Pavel V. Popryadukhin1,2, Olga M. Suvorova1, Alexander D. Vilesov1,2, Alena A. Popova3, Dmitry N. Suslov3

1 Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia
2 RM Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov University, St. Petersburg, Russia
3 A. M. Granov Russian Research Center of Radiology and Surgical Technologies, St. Petersburg, Russia

Contact: Prof. Oleg V. Galibin, phone: +7 (921) 906 1608, e-mail:

doi 10.18620/ctt-1866-8836-2020-9-3-1-152



Successful treatment of solid cancers is associated with an adequate use of potent and toxic anticancer drugs. To obtain the optimal result of chemotherapy, it is necessary to use the principle of achieving the maximum local effect of drugs on the tumor lesion focus. The most effective approach is to introduce the drug directly into the tumor, or regionally by means of a remote access, employing drug delivery systems (DS), which reduce their general toxic effect, prolonging the therapeutic effect due to gradual and time-controlled release of the drug in the tumor tissue. E.g., the CaCO3 nucleus as a complex with various polymers was previously used to form DS. The antitumor drug doxorubicin (DOC) was used as an active substance. It was shown in vitro that a pH-dependence and prolonged release effects take place.

Methods and results

Regional administration of DS was simulated in the experiment on rats with Seidel’s hepatoma inoculated into the abdominal cavity. The delivery vehicles containing DOC were injected directly into the abdominal cavity contaminated with tumor cells. As a result of the experimental study, the release of DOK from DS was shown within 7 days. In the control group with Seidel’s hepatoma, all animals (16 rats) died within 10-12 days. In experimental group, the maximum survival time of the animals was 180 days (2 rats). No tumor was found on autopsy. In the control group at the time of death, the volume of ascitic fluid was significantly less (P <0.05) than in animals of experimental group that died at the same time.


The obtained data confirm bioresoptive ability and safety of CaCO3 nuclei, making it possible to recommend such systems for further research as candidate drug delivery systems.


Delivery vehicles, CaCO3 nuclei, doxorubicin, Seidel hepatoma.

Volume 9, Number 3

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doi 10.18620/ctt-1866-8836-2020-9-3-1-152

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