Anemias in lymphomas: pathogenesis mechanisms
Anna S. Lyamkina, Tatiana I. Pospelova
The State Medical University, City Hematological Center, Novosibirsk, Russia
Summary
Aims
To spot the value of blood serum cytokines (IL-1β, IL-6, TNF-α, IF-γ) in the development of an anemic syndrome in patients with lymphoproliferative diseases.
Methods
We inspected 88 patients with lymphoproliferative diseases: T and B–cellular non–Hodgkin’s lymphomas and multiple myeloma. The level of serum interleukins (IL-1β, IL-6, TNF-α, IF-γ) was identified.
Results
Patients with lymphoproliferative diseases and an anemia had average levels of IL-1β, TNF-α, IF-γ in their blood serum that were 3.4, 2.8, and 14.4 times higher respectively than in patients with lymphomas without an anemia (p<0.05). The return correlation between levels of IL-1β, TNF-α, IF-γ and the level of erythropoietin serum (r=–0.79) confirms the importance of
IL-1β, TNF-α, IF-γ in an anemia pathogenesis at hemoblastoses. For 8.3% of patients with lymphomas and an anemia, myelodysplasia tags, recorded levels of IL-1β and TNF-α were twice as high as patients with normal erythron. This indicates a probable role of the researched cytokines in the development of secondary myelodysplasia in patients with lymphomas.
The return correlation between IL-6 and erythron of bone marrow was available in patients with multiple myeloma (r=–0.96). IL-6 raises a proliferation of myeloma cells, which, in turn, displace and depress a proliferation of remaining sprouts of myelopoiesis, including erythroid.
Conclusions
The cited data bears the importance of cytokines IL-1β, IL-6, TNF-α, and
IF-γ in a pathogenesis of an anemic syndrome for patients with lymphoproliferative diseases.
Keywords
cytokines, lymphoproliferative diseases, anemia, non-Hodgkin’s lymphoma, multiple myeloma
