ISSN 1866-8836
Клеточная терапия и трансплантация

LP-05. Stem cell mobilization and collection in HIV-positive patients with lymphoma: candidates to autologous HSCT

Yaroslava V. Komarova, Marina O. Popova, Andrey M. Chekalov, Ivan V. Tsygankov, Liliya V. Stelmakh, Lyudmila V. Fedorova, Kirill V. Lepik, Natalia B. Mikhailova, Maria A. Estrina, Elena V. Babenko, Maria D. Vladovskaya, Sergey N. Bondarenko, Ivan S. Moiseev, Alexander D. Kulagin

RM Gorbacheva Research Institute, Pavlov University, St. Petersburg, Russia


Contact: Yaroslava V. Komarova, phone: +7 (918) 043-17-31, e-mail: komarova.yaroslava@yandex.ru

doi 10.18620/ctt-1866-8836-2023-12-3-1-176

Summary

Autologous stem cell transplantation (ASCT) is an effective treatment to consolidate the remission in patients (pts) with recurrent/refractory lymphomas, even when they are AIDS-related lymphomas (ARL). ASCT is possible in case of successful hematopoietic stem cell (HSC) harvesting. Data of HSC harvesting in HIV positive (pos) pts with lymphomas are limited. Our aim was to evaluate the results of HSC harvesting in pts with ARL.

Materials and methods

A retrospective cohort of 30 pts with ARL as candidates to ASCT in RM Gorbacheva Research Institute from 2015 to 2023 was analyzed. The HIV negative (neg) pts with lymphomas were selected for comparison (n=30). An amount of ≥ 2×106 CD34+/kg was defined as successful collection. Pts characteristics are shown in the Table 1. Antiretroviral therapy was maintained in all pts with ARL.

Results

Overall HSC collection attempts were 34 in HIV pos and 37 in HIV neg pts. The results are outlined in Table 2. In HIV pos vs neg pts the harvest success was achieved at the 1st time in 77% (n=23) vs 77% (n=23), at the 2nd – in 10% (n=3) vs 17% (n=5), at the 3rd – only in HIV neg in 3% (n=1) pts, and in 13% (n=4) vs 3% (n=1) was a failure, respectively (p=0.428). Median CD34+/kg was 4 (3.2-5.3) vs 3 (1.6-4.1) in HIV pos vs neg pts, respectively (p=0.013).

Conclusion

Successful HSC harvesting was achieved in 26 (87%) pts with ARL. HSCs were harvested mainly at the 1st attempt by apheresis with CSF. Among HIV pos pts, the number of CD34+/kg was significantly higher (p=0.013), in the remaining results was no difference. To confirm these results and analyze the factors affecting the efficiency of the HSC harvesting, further research is required.

Keywords

Hematopoietic stem cell mobilization, HIV, lymphoma, apheresis, autologous stem cell transplantation, autologous.



Table 1. Characteristics of the patients under study

Komarova-tab01.jpg

Table 2. Results of stem cell harvesting

Komarova-tab02.jpg
Volume 12, Number 3 (Supplement)
09/30/2023

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doi 10.18620/ctt-1866-8836-2023-12-3-1-176

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