ISSN 1866-8836
Клеточная терапия и трансплантация

NM-03. Congenital giant nevi in children: problems of patients, methods and opportunities of treatment in Russia

Olga V. Filippova, Yaroslav N. Proshchenko, Dmitry I. Grigorov, Ekaterina N. Provorova

JSC «MEDSI Group», St. Petersburg, Russia

Contact: Olga V. Filippova, phone: +7 (911) 845-87-78, e-mail:

doi 10.18620/ctt-1866-8836-2023-12-3-1-176


The frequency of occurrence of patients with this malformation of the skin, according to various sources, varies within these limits – 1 child per 250-500 thousand people. In most cases, parents of children with giant nevi do not know where to go for observation and treatment, and pediatricians and pediatric oncologists do not know where to refer patients. Giant nevi are a serious problem that worsens the quality of life of a child, restricts sports, impairs social adaptation, and in some cases poses a threat to health.


Since the medium, large and giant nevi penetrate the entire thickness of the skin, and sometimes melanoform cells are also detected in the upper layers of the subcutaneous tissue, laser removal is either ineffective or gives a temporary and incomplete effect. A common picture after laser removal is a plane scar in the form of a nevus with areas of repigmentation.

The use of a “collagen matrix” after removal of extensive areas of the nevus leads to formation of rough pigmented scars and requires the additional use of skin autografting.

Removal of nevi over a large area with simultaneous plasty with a split perforated skin autograft leads to scarring of donor sites and scarring of the autograft itself, and, as a result, to unsatisfactory functional and aesthetic result.

More than 800 children with large and giant nevi have been treated at the MEDSI Center of the giant nevi treatment. Surgical approaches to the removal of nevi of various localizations have been developed. The accepted technique of expander dermotension has been improved and new approaches have been developed that allow obtaining full-thickness skin autografts of a large area in a short time, with minimal damage to the donor site.


The developed technique of surgical interventions provides good and excellent aesthetic results with full preservation of the function of the segments, contributes to the social rehabilitation of patients, reduces the risks associated with nevus and improves the quality of life.


Giant nevus, nevus treatment, melanoform nevus, children.

Supplement 12-3

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doi 10.18620/ctt-1866-8836-2023-12-3-1-176

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