ISSN 1866-8836
Клеточная терапия и трансплантация

DT-10. Analysis of the collection center activities at the National Medical Research Center for Hematology

Vera A. Vasilyeva, Olga S. Karavaeva, Feruza A. Omarova, Uliana V. Maslikova, Elmira I. Kolgaeva, Tatyana V. Gaponova, Larisa A. Kuzmina, Elena N. Parovichnikova

National Medical Research Center for Hematology, Moscow, Russia


Contact: Dr. Vera A. Vasilyeva, phone: +7 (916) 262-23-16, e-mail: vasilievaVA4@mail.ru

doi 10.18620/ctt-1866-8836-2023-12-3-1-176

Summary

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the therapy of choice for many patients with hematopoietic diseases. Despite world and Russian trends for increasing haploidentical HSCT, the proportion of allo-HSCT from unrelated donors remains significantly large (Passweg et al., 2022). According to the data of National Medical Research Center for Hematology (NMRCH), 36.3% of all allo-HSCTs were performed from unrelated donors in 2022, versus 47% in 2019, before the COVID-19 pandemic. We analyzed the work with unrelated donors of the Collection Center (CC) of the NRMCH. Our aim was to show the structure and effectiveness of procedures for activating and collection of hematopoietic stem cells (HSC) from a Russian unrelated donor at the CC of NMRCH.

Materials and methods

We analyzed the workup requests for activation and donation from the donors at NMRCH Registry from January 2020 to July 2023. During the activation process, donors filled a questionnaire and underwent complete medical examination before HSC donation. The mode of HSC donation was determined by the donor, but the donor was informed about the preferences of the center of transplantation (TC).

Results

135 workup requests for activation and HSC donation were received by the CC of NMRCH from January 2020 to July 2023 (121 requests for donors from the NMRCH Registry and 14, from other registries). 99 workup requests (73.3%) resulted into HSC donation. The reasons for failed donations (n=36) were as follows: donor refusal, 9 (25%); medical contraindications, except for bloodborne infections (BBI), 7; BBI (19.4%), 6 cases (16.7%). Some donations (n=14) were canceled by the transplant centers due to the following reasons: disease relapse, death of a patient, change of a donor, etc. (38.9%) as seen from Fig. 1.

In 21 cases (58.3%), cancellation of the workup requests preceded the medical examination of donors, and in 15 cases (41.7%) it occured after the medical checkup. The structure of the reasons for cancellation of workup requests is presented in Table 1.

Bone marrow was harvested in 5 of 99 donations (5.05%). In 94 cases (94.95%), the apheresis of HSCs was performed from peripheral blood.

Conclusion

Preparation for HSC donation is an important stage, which has a complex arrangement and methodology. We can draw several conclusions from the presented analysis in order to reduce the cancelation rates: it’s necessary to conduct advanced donor questionnaire survey before confirmatory typing to identify any already existing medical contraindications, as well as to check a donor for the presence of bloodborne infections before confirmatory typing. Inspiring are the results that not a single donor refused to donate after a medical examination.

References

Passweg J.R., Baldomero H., Chabannon C., et al. Impact of the SARS-CoV-2 pandemic on hematopoietic cell transplantation and cellular therapies in Europe 2020: a report from the EBMT activity survey. Bone Marrow Transplant. 2022;57(5):742.

Keywords

Unrelated donor, hematopoietic stem cells, donation, Russian Federation.


Vasylieva-03-fig01.jpg

Figure 1. Reasons of failed donations

Table 1. Reasons for cancellation of the workup requests

Vasylieva-03-tab01.jpg
Supplement 12-3
09/30/2023

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doi 10.18620/ctt-1866-8836-2023-12-3-1-176

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