ISSN 1866-8836
Клеточная терапия и трансплантация

DT-06. Experience with potential hematopoietic stem cells donors at the Russian Research Institute of Hematology and Transfusiology

Irina E. Pavlova, Elena V. Kuzmich, Sergey V. Sidorkevich, Lyudmila N. Bubnova

Russian Research Institute of Hematology and Transfusiology, St. Petersburg, Russia


Contact: Dr. Irina E. Pavlova, phone: +7 (812) 309-79-81, e-mail: pavlova@niigt.ru

doi 10.18620/ctt-1866-8836-2023-12-3-1-176

Summary

Arrangement and development of the Federal Bone Marrow Donors Register is aimed to increase the efficiency of the unrelated donors search for Russian patients requiring allogeneic hematopoietic stem cell transplantation (HSCT). The Russian Research Institute of Hematology and Transfusiology (RIHT) has been working with potential donors of hematopoietic stem cells (HSC) since 1988, the date of Bone Marrow Donor Register foundation at the Russian Center for Immunological Tissue Typing. The volunteers recruited and examined by our staff are currently joined to the Federal Bone Marrow Donor Register. The aim of our study was to analyze the work with potential hematopoietic stem cells donors during 2016-2022.

Results

A total of 8201 volunteers were attracted to the Register by the employees of the RIHT during 2016-2022. The volunteering cohort includes participants of 52 nationalities. Annual number of male subjects joining the registry exceeds the number of females. In 2022, the ratio of males to females was 60% vs 40%. During the entire period, there was a decrease in the median age of donors from 42 to 32 years. The initial of testing standards for the volunteers joining the Register has been also improved. The basic low-resolution HLA typing of HLA-A, -B, -DRB1 genes was carried out during 2016-2018. Over 2019-2022, the low-resolution basic HLA typing of HLA-A, -B, -C, -DRB1, -DQB1 genes was performed. Currently, high-resolution HLA typing is carried out by Sanger monoallelic DNA sequencing. Over the past time period, we received 863 search requests through the BMDS (Bone Marrow Donor Search) Russian Search Program. 842 search requests were received from Russian transplant centers; 21 search requests were from the transplant centers of the Republic of Kazakhstan. According to the results of high-resolution HLA typing, 9/10 or 10/10 HLA allele-matched donors were selected for 41 patients. 17 units of HSCs were harvested (14, peripheral blood stem cells; 3, bone marrow). 15 units of HSC were intended for patients of transplant centers in St. Petersburg, and 2 HSC products, for the transplant patients from other Russian ci-ties. HSC donation did not take place due to the issues at the transplantation center in 18 cases (choice of another HSCT mode – 8 cases; recruiting donor from another registry – 6 cases; complications/death of the patient just before HSCT – 4 cases). In 2 cases, HSC harvesting from potential donors was canceled for medical reasons upon pre-examination before donation. In four cases, the HLA-compatible donors still did not confirm their consent for donation due to objective circumstances.

Conclusion

The experience of Russian Research Institute of Hematology and Transfusiology with potential donors of hematopoietic stem cells over the period of 2016-2022 was analyzed. It was shown that the pool of potential donors is characterized by multi-ethnicity, predominance of males, a decrease in the median age of donors, thus certainly indicating a rationally arranged work aimed for attraction of volunteers to the Register.

Keywords

Donors, hematopoietic stem cells, donor registry.


Supplement 12-3
09/30/2023

Download PDF version

doi 10.18620/ctt-1866-8836-2023-12-3-1-176

Back to the list