Volume 5, number 1

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Volume 5, Number 1
03/01/2016

Editor-in-Chief
Afanasyev B. V. (St. Petersburg, Russia)

Co-Editors-in-Chief
Wagemaker G. (Rotterdam, Netherlands)
Zander A.R. (Hamburg, Germany)

Deputy Editor
Fehse B. (Hamburg, Germany)

Managing Editor
Chukhlovin A. B. (St. Petersburg, Russia)

Editorial Board
Aleynikova O. V. (Minsk, Belarus)
Baum C. (Hannover, Germany)
Bilko N. M. (Kyiv, Ukraine)
Borset M. (Trondheim, Norway)
Büchner Th. (Münster, Germany)
Chechetkin A. V. (St. Petersburg, Russia)
Fibbe W. (Leiden, Netherlands)
Galibin O. V. (St. Petersburg, Russia)
Gritsaev S. V. (St. Petersburg, Russia)
Hölzer D. (Frankfurt a.M., Germany)
Klimko N. N. (St. Petersburg, Russia)
Kolb H.-J. (München, Germany)
Kröger N. (Hamburg, Germany)
Kulagin A. D. (St. Petersburg, Russia)
Lange C. (Hamburg, Germany)
Mamaev N. N. (St. Petersburg, Russia)
Mikhailova N. B. (St. Petersburg, Russia)
Moiseev I. S. (St. Petersburg, Russia)
Nagler A. (Tel-Aviv, Israel)
Nemkov A. S. (St. Petersburg, Russia)
Paramonov I. V. (Kirov, Russia)
Roumiantsev A. G. (Moscow, Russia)
Savchenko V. G. (Moscow, Russia)
Smirnov A. V. (St. Petersburg, Russia)
Uss A. L. (Minsk, Belarus)
Zubarovskaya L. S., (St.Petersburg, Russia)

Editorial Council

In this Issue

Despite a wide scope of the CTT editorial policy, hematopoietic stem cell transplantation (HSCT) and related topics remain central to our readership, due to advanced research in this field. Chronic myeloid leukemia (CML) is the example of such a fast evolution in diagnostics and therapy over last decades. A review article by Rüdiger Hehlmann and Susanne Saußele illustrates differential approaches with tyrosine kinase inhibitors (TKIs) and HSCT as first- and second-line strategies of CML treatment, with regard to individual risk factors, thus providing optimal outcomes in terms of overall survival and achieving molecular remissions.

Clinical efficiency of leukemia treatment is now measured by dropping levels of specific oncogenic markers after the therapy performed. Professor Robert P. Gale presents an elegant article dedicated to accuracy of molecular tests, aiming efficiency evaluation and improved quality of the leukemia relapse prediction. The article will be of value to both clinicians and laboratory hematologists.

The usage of autologous marrow stem cells transplantation for treatment of myocardial disorders still remains under discussion. In spite of positive clinical effects of such treatment in certain cases, there are some controversies concerning engraftment and long-term in situ effects of the stem cells injected. In this respect, the article from a German team lead by Professor Steinhoff is of special interest. A comprehensive description of cardiological effects following auto-HCST of CD133+ cells is given in this review, as based on follow-up of 223 patients from the RTC Registry. A need for further trials is suggested.

A short article Time- and sample-dependent differences in polyomavirus incidence following hematopoietic stem cell transplantation is dedicated to reactivation of polyomaviruses in immunocompromised patients, being a common consequence of the post-HSCT immune deficiency. E. g., the BK virus in urinary cells is generally associated with hemorrhagic cystitis after cytostatic treatment.

This issue also contains a collection of poster communications prepared by the workers from Russia, Belarus, Armenia, and Tajikistan and presented at the VIII Raisa Gorbacheva Memorial Meeting (September
18-22, 2015, Sochi, Russia). These abstracts provide a short view of the topics that are currently in scope of HSCT specialists working in the ex-USSR countries.

The CTT Journal also regrets upon the loss of Professor van Bekkum, a leader in hematopoietic stem cell research. An obituary written by G. Wagemaker is placed in this issue of the Journal.

Regular articles

Long-term results of intramyocardial CD133+ bone marrow stem cell therapy for myocardial ischemia: experience with stem cell register

Julia Nesteruk, Gustav Steinhoff

Monitoring Therapy-Response in acute myeloid leukemia

Robert Peter Gale

Time- and sample-dependent differences in polyomavirus incidence following hematopoietic stem cell transplantation

Alexey B. Chukhlovin¹, Yury A. Eismont², Vladimir N. Vavilov¹, Ludmilla S. Zubarovskaya¹, Boris V. Afanasyev¹

First- and second-line strategies in chronic phase CML including hematopoietic stem cell transplantation

Rüdiger Hehlmann, Susanne Saußele

Short messages

Effectiveness of high-dose chemotherapy with autologous stem cell transplantation (ASCT) in patients with relapsed and refractory course of Hodgkin’s lymphoma

Elena V. Kondakova, Natalya B. Mikhailova, Evgenia S. Borsenkova, Olga B. Kalashnikova, Nadezhda V. Medvedeva, V. V. Ryabchikova, Boris V. Afanasyev

Hematopoietic stem cell transplantation in patients with neurometabolic diseases: a single center experience

Kirill I. Kirgizov1, 2, Ekaterina A. Pristanskova¹, Yulia V. Skvortsova², Natalia L. Pechatnikova¹, Marina Y. Persiantseva², Natalia V. Sidorova¹, Dmitry N. Balashov², Veronika V. Konstantinova¹, Oxana L. Blagonravova¹, Svetlana M. Mikhailova¹, Elena V. Skorobogatova¹, Aleksey A. Maschan²

Aberrant methylation of promoter regions of sox7, p15ink4b and WNT pathway antago- nist genes in patients with myelodysplas- tic syndrome

Ivan I. Kostroma, Sergey V. Gritsaev, Zh. Yu. Sidorova, S. A. Tiranova, S. P. Svitina, Yulia S. Drizhun, Irina S. Martinkevitch, Kudrat M. Abdulkadyrov, Sergej I. Kapustin, Alexander V. Chechetkin

Chimerism analysis after allogeneic hematopoietic stem cell transplantation as a prognostic factor of relapse in hematopoietic malignancies in children

Victoria A. Lavrinenko, Yulia E. Mareiko, Tatsiana V. Savitskaya, Mikhail V. Belevtsev, Olga V. Aleynikova

Low-dose cytarabine and cladribine for treatment of relapsed or refractory acute myeloid leukemia: clinical experience

Sergej V. Gritsaev, Ivan I. Kostroma, Anastasia A. Kuzjaeva, Irina M. Zapreeva, Elena V. Litvinskaya, Lubov V. Steljmashenko, S. A. Tiranova, Irina S. Martinkevitch, Nadezhda A. Potichonova, Kudrat M. Abdulkadyrov.

Mesenchymal stem cells: multilayer polyelectrolyte microcapsules uptake, toxicity and influence upon functional properties

K. V. Lepik¹, V. S. Sergeev¹, A. R. Muslimov¹, D. S. Romanyuk¹, R. T. Mikhelashvili¹, I. S. Moiseev¹, E. V. Popova²,I. L. Radchenko², A. D. Vilesov¹, G. B. Sukhorukov^{2, 3}, B. V. Afanasyev¹

Results of high-dose chemotherapy with autologous hematopoietic stem cell transplantation in treatment of pediatric brain tumors

Asmik G. Gevorgian¹, Elena V. Morozova¹, Ilya V.Kazantsev¹, Tatiana V. Iukhta¹, Svetlana A. Safonova¹, Yury A. Punanov¹, Ludmila S. Zubarovskaya¹, Olga G. Zheludkova², Boris V. Afanasyev¹

Allogeneic stem cell transplantation in myelofibrosis patients with intermediate-2 and high DIPSSplus risk

Maria V. Barabanshikova, Elena V. Morozova, Vadim V. Baikov, Ludmila S. Zubarovskaya, Boris V. Afanasyev

Epidemiology and risk factors for bacterial infections (BI) in children and adolescents after allogeneic hematopoietic stem cell transplantation (allo-HSCT)

Maria Yu. Averianova¹, Vladimir N. Vavilov¹, Natalia V. Stancheva¹, Svetlana V. Razumova¹, Anastasia S. Borovkova¹, Olesya V. Paina¹, Polina V. Kozhokar¹, Kirill A. Ekushov¹, Andrey V. Kozlov¹, Yulia G. Fedukova¹, Inna V. Markova¹, Yana V. Gudozhnikova¹, Anna A. Spiridonova¹, Nadezhda А. Schaliapina², Svetlana A. Riachovskych², Anna V. Lubimova², Ludmila S. Zubarovskaya¹, Boris V. Afanasyev¹

Prevalence of hematological malignancies in Armenia

Smbat S. Daghbashyan, Nata A. Melkikyan, Lussine.S. Sahakyan, M.V.Saharyan, R.Yolyan

Significance of matrix metalloproteinase-9 evaluation in the bone marrow plasma from the patients with acute myeloid leukemia and myelodysplastic syndrome

I. F. Lesnichenko, Sergej V. Gritsaev, Ivan I. Kostroma

Impact of cytogenetics on outcome of acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation

Tatiana L. Gindina, Nikolay N. Mamaev, Sergey N. Bondarenko, Alexander L. Alyanskiy , Olga A. Slesarchuk, Ivan S. Moiseev, Olga V. Pirogova, Svetlana V. Razumova, Lyudmila S. Zubarovskaya, Boris V. Afanasyev

17q21→17qter jumping translocations in a 13-year-old girl with RUNX1–RUNX1T1- positive acute myeloid leukemia

Tatiana L. Gindina, Nikolay N. Mamaev, Elena S. Nikolaeva, Olga S. Uspenskaya, Irina A. Petrova, Marya Yu. Averyanova, Sergey N. Bondarenko, Boris V.Afanasyev

Influence of co-transplanted mesenchymal stem cell upon immunological recovery after allogeneic hematopoietic cell transplantation in children

Yuliya E. Mareika, Tatiana V. Shman, Yanina I. Isaikina, Nina V. Minakovskaya, Natalia P. Kirsanava, Olga V. Aleynikova

Long-term observations of patients with Fanconi anemia following allogeneic hematopoietic stem cell transplantation: a two-center experience

Elena V. Skorobogatova¹, Kirill I. Kirgizov¹, Dmitry N. Balashov², Natalia V. Sidorova¹, Ekaterina A. Pristanskova¹, Natalia V. Sidorova¹, Veronika V. Konstantinova¹, Oxana L. Blagonravova¹, Pavel E. Trakhtman², Yulia V. Skvortsova², Michael A. Maschan², Aleksey A. Maschan²

Efficiency of antimicrobial surface treated central venous catheters in the prophylaxis of catheter-associated infections in children with oncohematological diseases

Yulia Simakina, Olga Ivanova, Elisa Kubieva, Elena V. Morozova, Ekaterina Goncharova, Ludmila S. Zubarovskaya, Boris V. Afanasyev

10/10 compatibility in hematopoietic stem cell transplantations (HSCT) may improve outcomes as compared to 9/10: a single-center study

Natalia V. Sidorova¹, Kirill I. Kirgizov¹, Dmitry N. Balashov², Pavel E. Trachtman², Marina Y. Persiantseva², Ekaterina A. Pristanskova¹, Veronika V. Konstantinova¹, Oxana L. Blagonravova¹, Michael A. Maschan², Elena V. Skorobogatova¹, Alexey A. Maschan²

Early diagnostics of acute kidney injury (AKI) associated with hematopoietic stem cell transplantation (HSCT)

Kirill A. Smirnov, Vladimir A. Dobronravov, Boris V. Afanasiev, Olga V. Galkina, Irina M. Zubina, Evdokia O. Bogdanova

Genomic DNA breakpoints in MLL and translocation partner genes: correspondence to clinical parameters and treatment outcome in infants with acute leukemia

Grigory A. Tsaur¹, Claus Meyer², Anatoly M. Kustanovich³, Alexander M. Popov¹, Tatiana O. Riger¹, Elena W. Fleischman⁴, Olga I. Sokova⁴, Yulia V. Olshanskaya⁵, Elena А. Matveeva⁵, Olga V. Streneva¹, Egor V. Shorikov¹, Leonid I. Saveliev⁶, Rolf Marschalek², Larisa G. Fechina¹

Effective treatment of mixed viral infection in a patient after haploidentical stem cell transplantation

Larisa Vakhonina^{1, 2}, Igor Vyatkin^{1, 2}, Natalya Maysheva^{1, 2}, Grigory Tsaur^{1, 2, 3}, Oleg Medvedev^{1, 2}, Leonid Saveliev^{1, 2, 3}, Larisa Fechina^{1, 2}

Evaluation of bone marrow stromal cells regarding their role in hematopoietic reconstitution

Nikolai Y. Tsvetkov, Ildar M. Barkhatov, Alain I. Shakirova, Dmitri S. Romaniuk, Olesya G. Smykova, Vera V. Teplyashina, Ludmila S. Zubarovskaya, Boris V. Afanasyev

Evaluation of posttransplant relapse risk in patients with acute leukemia using the gene expression markers

Alena I. Shakirova¹, Ildar M. Barkhatov¹, Olga I. Shakirova², Dmitry S. Romanyuk¹, Alexei V. Evdokimov¹,

Sergey N. Bondarenko¹, Ludmila S. Zubarovskaya¹, Boris V. Afanasyev¹

Efficiency of hypoxic hypoxia during idiopathic thrombocytopenic purpura

Abduhalim R. Raimzhanov¹, Irina A. Tsopova², Mary O. Eralieva¹, Bahtygul K. Aysarieva³

Instant lysis of therapeutic mesenchymal stem cells after intravenous infusion: role of complement system and in vitro prevention strategies

A. R. Muslimov, R. T. Mikhelashvili, E. V. Volchkov, K. V. Lepik, V. S. Sergeev, B. V. Afanasyev

Treatment of refractory chronic graft-versus-host disease with interleukin-2

Ivan S. Moiseev, E.A. Burmina, Olga V. Pirogova, Olga A. Slesarchuk, Sergej N. Bondarenko, Boris V. Afanasyev

Pharmacokinetic comparison of cyclosporine A and tacrolimus for graft-versus-host disease prophylaxis

Moiseev Ivan S., Muslimov A. R., Pirogova Olga V., Darskaya Elena I., Slesarchuk Olga A., Bondarenko Sergej N., Afanasyev Boris V.

Efficiency and safety of 5-azacitidine administration in acute myeloid leukemia and myelodisplastic syndrome after allogenic hematopoietic stem cell transplantation

Varvara N. Ovechkina, Sergey N. Bondarenko, Elena V. Morozova, Olga A. Slesarchuk, Anna G. Smirnova, Kirill A. Ekushov, Ludmila S. Zubarovskaya, Boris V. Afanasyev

Characteristics of early posttransplant phase in patients with multiple myeloma and different response to standard chemotherapy: single-center analysis of 130 cases

Galina D. Petrova, Kapitolina N. Melkova, Tatiana Z. Chernyavskaya, Nadezhda V. Gorbunova, Valentina N. Kostrykina, Vadim A. Doronin.

Treatment of HIV-associated lymphomas: results of a multicenter retrospective study

Popova M.¹, Shneyder T.², Karaygin I.², Zuyzgin I.2, 10, Ryabykina O.², Ruzhinskaya O.², Uspenskaya O.², Medvedeva N.³, Klimovich A.³, Potapenko V.³, Kotova N.³, Zinina E.⁴, Popova N.⁴, Zhurba Y.⁴, Myasnikov A.⁵, Moshnina S.⁵, Evseev A.⁵, Kaplanov K.⁶, Ksenzova T.⁷, Karyagina E.⁸, Stolypina Zh.⁸, Dzola S.⁹, Levanov A.⁹, Mel’sitova K.¹, Borzenkova E.¹, Mikhaylova N.¹, Zubarovskaya L.¹ and Afanasyev B.¹

Graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide

Olga V. Pirogova, Ivan S. Moiseev, Elena I. Darskaya, Sergej N. Bondarenko, Elena V. Babenko, Alexander L. Alyanskiy, Boris V. Afanasyev

Obituary

Dirk Willem van Bekkum 30 Juli 1925 - 17 Juli 2015

Gerard Wagemaker